The S-DISCO programme originates from longstanding informal discussions between some of the partners on the need to train students in drug discovery, the challenging phase in the life cycle of a medicine that precedes first-in-human studies and clinical development. The programme is unique in that it will pay notable attention to sustainability, an aspect that currently receives little attention in traditional educational programmes in this area. Sustainability boundaries, including environmental, ecological and socio-economic dimensions, add an extra level of complexity to drug discovery, but are of increasing importance to competent authorities and the society at large. The new S-DISCO programme, coordinated by Ghent University, is a two-year Master programme consisting of logically aligned modules with stepwise build-up knowledge, skills and competences. By applying case-based learning, it will stimulate students to integrate, connect, confront and reconcile multi-perspective ways of looking at sustainable drug discovery.